More Information About ICAM 1
- See also: Cell adhesion molecule
ICAM-1 (Inter-Cellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a human gene.[1][2]
Function
The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα), and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes binds to endothelial cells via ICAM-1/LFA-1 and then transmigrates into tissues.[3]
Clinical significance
ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies.[4][5] While ICAM-1 has not been shown to be directly correlated with cerebral vasospasm, a secondary insult which affects 70% of SAH patients, treatment with anti-ICAM-1 reduced the severity of vasospasm.
References
- ^ Carlson M, Nakamura Y, Payson R, O'Connell P, Leppert M, Lathrop GM, Lalouel JM, White R (May 1988). "Isolation and mapping of a polymorphic DNA sequence (pMCT108.2) on chromosome 18 [D18S24]". Nucleic Acids Res. 16 (9): 4188. PMID 2453850. PMC: 336612. http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=2453850.
- ^ Katz FE, Parkar M, Stanley K, Murray LJ, Clark EA, Greaves MF (January 1985). "Chromosome mapping of cell membrane antigens expressed on activated B cells". Eur. J. Immunol. 15 (1): 103–6. PMID 3871395.
- ^ Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW (July 2005). "ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow". Blood 106 (2): 584–92. doi:10.1182/blood-2004-12-4942. PMID 15811956.
- ^ Polin RS, Bavbek M, Shaffrey ME, Billups K, Bogaev CA, Kassell NF, Lee KS (October 1998). "Detection of soluble E-selectin, ICAM-1, VCAM-1, and L-selectin in the cerebrospinal fluid of patients after subarachnoid hemorrhage". J. Neurosurg. 89 (4): 559–67. PMID 9761049.
- ^ Frijns CJ, Kappelle LJ (August 2002). "Inflammatory cell adhesion molecules in ischemic cerebrovascular disease". Stroke 33 (8): 2115–22. PMID 12154274. http://stroke.ahajournals.org/cgi/pmidlookup?view=long&pmid=12154274.
Further reading
- Wahl SM, Greenwell-Wild T, Hale-Donze H, et al. (2000). "Permissive factors for HIV-1 infection of macrophages.". J. Leukoc. Biol. 68 (3): 303–10. PMID 10985244.
- Yonekawa K, Harlan JM (2005). "Targeting leukocyte integrins in human diseases.". J. Leukoc. Biol. 77 (2): 129–40. doi:10.1189/jlb.0804460. PMID 15548573.
- Chakravorty SJ, Craig A (2005). "The role of ICAM-1 in Plasmodium falciparum cytoadherence.". Eur. J. Cell Biol. 84 (1): 15–27. PMID 15724813.
- Lebedeva T, Dustin ML, Sykulev Y (2005). "ICAM-1 co-stimulates target cells to facilitate antigen presentation.". Curr. Opin. Immunol. 17 (3): 251–8. doi:10.1016/j.coi.2005.04.008. PMID 15886114.
- Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW (2005). "ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.". Blood. 106 (2): 584–92. doi:10.1182/blood-2004-12-4942. PMID 15811956.
External links
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Proteins: clusters of differentiation (see also list of human clusters of differentiation) |
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| 1-50 |
CD1 ( a-c, 1A, 1D, 1E) - CD2 - CD3 ( γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 ( a) - CD9 - CD10 - CD11 ( a, b, c) - CD13 - CD14 - CD15 - CD16 ( A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 ( A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 ( a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 ( a, b, c, d, e, f) - CD50
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| 51-100 |
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 ( E, L, P) - CD63 - CD64 - CD66 ( a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD78 - CD79 ( a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 ( a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
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| 101-150 |
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| 151-200 |
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 ( a, b, c) - CD157 - CD158 ( a, d, e, i, k) - CD159 ( a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 ( a, b) - CD168 - CD169 - CD170 - CD171 - CD172 ( a, b, g) - CD174 - CD177 - CD178 - CD179 ( a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
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| 201-250 |
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| 251-300 |
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| 301-350 |
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