More Information About P2RY1
Purinergic receptor P2Y, G-protein coupled, 1, also known as P2RY1, is a human gene.
The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[1]
See also
References
External links
- "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
- Ayyanathan K, Webbs TE, Sandhu AK, et al. (1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor.". Biochem. Biophys. Res. Commun. 218 (3): 783–8. doi:10.1006/bbrc.1996.0139. PMID 8579591.
- Janssens R, Communi D, Pirotton S, et al. (1996). "Cloning and tissue distribution of the human P2Y1 receptor.". Biochem. Biophys. Res. Commun. 221 (3): 588–93. doi:10.1006/bbrc.1996.0640. PMID 8630005.
- Léon C, Vial C, Cazenave JP, Gachet C (1996). "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.". Gene 171 (2): 295–7. PMID 8666290.
- Léon C, Hechler B, Vial C, et al. (1997). "The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells.". FEBS Lett. 403 (1): 26–30. PMID 9038354.
- Ayyanathan K, Naylor SL, Kunapuli SP (1997). "Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1).". Somat. Cell Mol. Genet. 22 (5): 419–24. PMID 9039850.
- Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.
- Jin J, Daniel JL, Kunapuli SP (1998). "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets.". J. Biol. Chem. 273 (4): 2030–4. PMID 9442040.
- Hall RA, Ostedgaard LS, Premont RT, et al. (1998). "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8496–501. PMID 9671706.
- Sabala P, Czajkowski R, Przybyłek K, et al. (2001). "Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells.". Br. J. Pharmacol. 132 (2): 393–402. doi:10.1038/sj.bjp.0703843. PMID 11159687.
- Yoshioka K, Saitoh O, Nakata H (2001). "Heteromeric association creates a P2Y-like adenosine receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7617–22. doi:10.1073/pnas.121587098. PMID 11390975.
- James G, Butt AM (2001). "Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve.". Neurosci. Lett. 312 (1): 33–6. PMID 11578839.
- Moore DJ, Chambers JK, Wahlin JP, et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.". Biochim. Biophys. Acta 1521 (1-3): 107–19. PMID 11690642.
- Czajkowski R, Lei L, Sabała P, Barańska J (2002). "ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12).". FEBS Lett. 513 (2-3): 179–83. PMID 11904146.
- Aktas B, Hönig-Liedl P, Walter U, Geiger J (2002). "Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase.". Biochem. Pharmacol. 64 (3): 433–9. PMID 12147294.
- Nurden P, Poujol C, Winckler J, et al. (2003). "Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system.". Blood 101 (4): 1400–8. doi:10.1182/blood-2002-02-0642. PMID 12393588.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.". J. Invest. Dermatol. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858.
- Jagroop IA, Burnstock G, Mikhailidis DP (2003). "Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets.". Platelets 14 (1): 15–20. PMID 12623443.
- Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.". J. Invest. Dermatol. 120 (6): 1007–15. PMID 12787128.
- Wang L, Ostberg O, Wihlborg AK, et al. (2003). "Quantification of ADP and ATP receptor expression in human platelets.". J. Thromb. Haemost. 1 (2): 330–6. PMID 12871508.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Transmembrane receptor: G protein-coupled receptors |
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| Class A: Rhodopsin like |
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GPR ( 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172A, 173, 174, 176, 177, 182)
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Adenosine ( A1, A2a, A2b, A3) • P2Y ( 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
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Other
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Acetylcholine ( M1, M2, M3, M4, M5) • Adrenomedullin • Anaphylatoxin ( C3a, C5a) • Angiotensin ( 1, 2) • Apelin • Bile acid • Bombesin ( BRS3, GRPR, NMBR) • Bradykinin ( B1, B2) • Cannabinoid ( CB1, CB2) • Chemokine • Cholecystokinin ( A, B) • Dopamine ( D1, D2, D3, D4, D5) • EBI2 • Endothelin ( A, B) • Estrogen • Formyl peptide ( 1, L1, L2) • Free fatty acid ( 1, 2, 3, 4) • FSH • Galanin ( 1, 2, 3) • Gonadotropin-releasing hormone ( 1, 2) • Ghrelin • Histamine ( H1, H2, H3, H4) • Kisspeptin • Luteinizing hormone/choriogonadotropin • Lysophospholipid ( 1, 2, 3, 4, 5, 6, 7, 8) • MAS ( 1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanocortin ( 1, 2, 3, 4, 5) • MCHR ( 1, 2) • Melatonin ( 1A, 1B) • Motilin • Opioid ( Delta, Kappa, Mu, Nociceptin, but not Sigma) • Olfactory • Opsin ( 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Orexin ( 1, 2) • Oxytocin • Oxoglutarate • PAF • Prokineticin ( 1, 2) • Prolactin-releasing peptide • Protease-activated ( 1, 2, 3, 4) • Relaxin ( 1, 2, 3, 4) • Somatostatin ( 1, 2, 3, 4, 5) • SREB • Succinate • TAAR ( 1, 2, 3, 5, 6, 8, 9) • Tachykinin ( 1, 2, 3) • Thyrotropin • Thyrotropin-releasing hormone • Urotensin-II • Vasopressin ( 1A, 1B, 2)
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| Class B: Secretin like |
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GPR ( 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157)
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Other
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Brain-specific angiogenesis inhibitor ( 1, 2, 3) • Cadherin ( 1, 2, 3) • Calcitonin • CALCRL • CD97 • Corticotropin-releasing hormone ( 1, 2) • EMR ( 1, 2, 3) • Glucagon ( GR, GIPR, GLP1R, GLP2R) • Growth hormone releasing hormone • PACAPR1 • GPR • Latrophilin ( 1, 2, 3, ELTD1) • Parathyroid hormone ( 1, 2) • Secretin • Vasoactive intestinal peptide ( 1, 2)
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Class C: Metabotropic
glutamate / pheromone |
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TAS1R ( 1, 2, 3) • TAS2R ( 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50)
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Other
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Calcium-sensing receptor • GABA B ( 1, 2) • Glutamate receptor ( Metabotropic glutamate ( 1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR ( 156, 158, 179) • RAIG ( 1, 2, 3, 4)
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| Frizzled / Smoothened |
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